Both diseases result in chronic, systemic inflammation with increased circulating populations of leukocytes, lymphocytes, cytokines, and chemokines (predominantly Th2 pathways in AD vs. ĪD and psoriasis are caused by a complex interplay between skin-barrier disruption, immune dysregulation, host genetics, and environment triggers. Both AD and psoriasis are strongly associated with poor health-related quality of life (QOL), high direct and indirect costs of care, and significant societal cost-highlighting a need for optimal disease control. Psoriasis is associated with rheumatologic (psoriatic arthritis), cardiovascular, metabolic, hepatic, and psychiatric disease. AD is associated with higher rates of mental health symptoms and disorders, including depression, anxiety, and attention-deficit (hyperactivity) disorder, sleep dysregulation, other atopic disorders (e.g., asthma, hay fever), cardiovascular disease, stroke, and obesity. Though both AD and psoriasis were once considered to be skin-limited disorders, emerging evidence suggests a substantial systemic burden of disease. Atopic dermatitis (AD) and psoriasis are chronic, inflammatory skin diseases associated with considerable morbidity.
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